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My experience so far combining CBD oil with Lexapro: It My experience so far combining CBD oil with Lexapro: It helps! So I've been taking CBD oil daily for about 2 weeks now on top of my lexapro and feel like the results have been promising. I figured this might help some of you who would like something to work along side of your Lexapro. Can You Mix CBD and Lexapro? - Side Effects / Interactions Interactions Between CBD and Lexapro. Lexapro is an orally administered antidepressant and is considered to be a selective serotonin reuptake inhibitor (SSRI). Just like CBD, SSRIs like Lexapro affect the endocannabinoid system – one of the most prominent nerve systems in the human body.

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